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編號：BJBAG2001
中文品名：鏈脲佐菌素 、鏈脲霉素
英文名稱：Streptozocin
≥75% α-anomer basis, ≥98% (HPLC), powder
CAS號 18883-66-4
經(jīng)驗分子式（希爾表示法） C8H15N3O7
分子量 265.22
基本信息
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Related Categories |
Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, 一氧化氮代謝, 一氧化氮和細(xì)胞應(yīng)激, 抗生素, 生化試劑, 生物活性小分子, 細(xì)胞信號轉(zhuǎn)導(dǎo)和神經(jīng)科學(xué), 細(xì)胞生物學(xué), 酶、抑制劑和底物 更多... |
|
InChI Key |
ZSJLQEPLLKMAKR-GKHCUFPYSA-N |
|
assay |
≥75% α-anomer basis |
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|
≥98% (HPLC) |
|
form |
powder |
|
color |
white to light yellow |
|
mp |
121 °C (dec.) (lit.) |
|
Mode of action |
DNA synthesis | interferes |
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antibiotic activity spectrum |
neoplastics |
|
originator |
Pfizer |
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storage temp. |
−20°C |
一種在胰島中可作為一氧化氮供體的含N-亞硝基化合物；誘導(dǎo)胰島素分泌細(xì)胞的死亡，產(chǎn)生糖尿病動物模型?？烧T導(dǎo)染色體斷裂的有效DNA甲基化劑。 對表達(dá)GLUT2葡萄糖轉(zhuǎn)運(yùn)蛋白的神經(jīng)內(nèi)分泌腫瘤細(xì)胞系具有細(xì)胞毒性。
技術(shù)規(guī)格說明書
FT-IR Condensed Phase
FT-IR Raman
FT-NMR
S0130 - Product Information Sheet (57 KB)
安全信息
Danger
危害聲明
個人防護(hù)裝備
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害碼 (歐洲)
T
風(fēng)險聲明 (歐洲)
45
安全聲明 (歐洲)
53-45
RIDADR
UN 3077 9 / PGIII
WGK德國
3
RTECS
LZ5775000
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How should I store Product S0130, Streptozocin, upon receipt?
Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.
How do I store solutions of Product S0130, Streptozocin?
Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.
What is the half-life of Product S0130, Streptozocin?
Streptozocin has a reported half life of 15 to 30 minutes.
How can I make a solution of Product S0130, Streptozocin?
This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.
CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?
We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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發(fā)現(xiàn)用于一氧化氮和細(xì)胞應(yīng)激研究的生物活性小分子
接觸惡劣條件、細(xì)胞損傷和其他因素都可能造成細(xì)胞應(yīng)激。由氧直接和間接催生的應(yīng)激稱為氧化應(yīng)激，這是由于氧化劑產(chǎn)生的增加、抗氧化劑保護(hù)降低或不能修復(fù)由活性氧物質(zhì)(ROS)誘導(dǎo)的氧化損傷所致。多種途徑參與細(xì)胞產(chǎn)生ROS，包括線粒體電子傳遞鏈(ETC)、炎癥信號傳導(dǎo)和內(nèi)質(zhì)網(wǎng)(ER)應(yīng)激。過量ROS可以激活應(yīng)激激活信號級聯(lián)或誘導(dǎo)改變大分子，如膜脂、DNA和必需蛋白（包括線粒體蛋白）。細(xì)胞應(yīng)激過程能夠激活應(yīng)激...
同行評議文獻(xiàn)
Did you use this product in your Paper? If so click here.
The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)
Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)
Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? Marco Analytical Biochemistry 504, 38-40, (2016)
Acute stimulation of brain mu opioid receptors inhibits glucosestimulated insulin secretion via sympathetic innervation Eva Tuduri Neuropharmacology 110, 322-332, (2016)
Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice Sung-Hsun Yu PLoS ONE , -, (2016)
read abstract
Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.
Patrick Reeson et. al
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), undefined (2015-4-4)
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Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
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貨號 |
商品名稱 |
級別 | 規(guī)格 |
|
BJBAG2002 |
檸檬酸 |
AR |
10g/瓶 |
| BJBAG2003 | 檸檬酸鈉 | AR | 10g/瓶 |
| BJBAG2004 | 二甲雙胍 | 原料藥 | 25g/瓶 |
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